CIPROFLOXACIN
(Cipro)Standard Prescription
ciprofloxacin__mg PO Q__H (__mg/kg/day)
ciprofloxacin__mg IV Q__H (__mg/kg/day)
ciprofloxacin__mg IV Q__H (__mg/kg/day)
Dosages
Oral: 10-20 mg/kg/dose PO BID. Max: 750 mg/dose
For Pseudomonas aeruginosa treatment: 10 mg/kg/dose IV Q8H. Max: 400 mg/dose
IV: 10 mg/kg/dose IV Q8H. Max: 400 mg/dose
1-2 drops q2h while awake x 2 days, then 1-2 drops q4h while awake x 5 days
Day 2: 2 drops Q1H
Days 3-14: 2 drops Q4H
IV: 10-15 mg/kg/dose IV Q12H. Max 400 mg/dose
Cystic Fibrosis Patients:
Oral: 20 mg/kg/dose PO Q12H. Max: 1000 mg/doseIV: 10 mg/kg/dose IV Q8H. Max: 400 mg/dose
Eye drops:
Bacterial conjunctivitis:1-2 drops q2h while awake x 2 days, then 1-2 drops q4h while awake x 5 days
Corneal ulcers:
Day 1: 2 drops Q15 min. x 6 hr, then 2 drops Q30 minsDay 2: 2 drops Q1H
Days 3-14: 2 drops Q4H
Mechanism of Action
Fluoroquinolone antibiotic
Forms Supplied
tablet: 250 mg, 500 mg
oral suspension: 100 mg/mL
injection: 2 mg/mL
eye drops: 0.3%
oral suspension: 100 mg/mL
injection: 2 mg/mL
eye drops: 0.3%
Comments
Bioavailability 70-80%.
Ciprofloxacin suspension should not be administered through G-tubes as blockage can result.
Not routinely first-line therapy, but can be considered a reasonable alternative in some situations.
Monitor for arthralgias, tendonitis and maintain fluid intake to prevent crystalluria.
Ciprofloxacin can increase effects and/or toxicity of theophylline, warfarin, cyclosporine and caffeine
Avoid concomitant administration with divalent or trivalent cations (e.g. antacids, iron Fe 3+, calcium supplements Ca 2+ ), sucralfate; space doses by 2-6 hours.
Ciprofloxacin suspension should not be administered through G-tubes as blockage can result.
Not routinely first-line therapy, but can be considered a reasonable alternative in some situations.
Monitor for arthralgias, tendonitis and maintain fluid intake to prevent crystalluria.
Ciprofloxacin can increase effects and/or toxicity of theophylline, warfarin, cyclosporine and caffeine
Avoid concomitant administration with divalent or trivalent cations (e.g. antacids, iron Fe 3+, calcium supplements Ca 2+ ), sucralfate; space doses by 2-6 hours.
References
6, 44, 46, 76, 474
Last Edited
2022-06-16 01:05:59