CLOXACILLIN
Standard Prescription
cloxacillin__mg IV/IM{PO} Q__H (__mg/kg/24hr)
Dosages
Mild to Moderate Infections:
Severe Infections:
50 mg/kg/dose IV Q4-6H
Cystic Fibrosis:
50 mg/kg/dose IV Q4-6H. Max 2000 mg/dose
IV: 25-50 mg/kg/dose IV Q6H Max 2000 mg/dose
50 mg/kg/dose IV Q4-6H
Max 2000 mg/dose
50 mg/kg/dose IV Q4-6H. Max 2000 mg/dose
Adults:
1-2 g/dose IV Q4-6H Mechanism of Action
Penicillin antibiotic
Forms Supplied
injection: 250mg, 500 mg, 1 g, 2 g/vial
Comments
Oral cloxacillin is poorly absorbed (bioavailability ~50%, reduced by food).
Consider using cephalexin as oral-stepdown in place of oral cloxacillin, as cephalexin has higher bioavailability, is more palatable and causes less GI upset.
References
6, 44, 228, 305
Last Edited
2022-06-16 01:40:55