CODEINE
Standard Prescription
codeine__mg PO Q__H (__mg/kg/dose) (prn pain)
Dosages
Analgesia:
0.5 to 1 mg/kg/dose PO Q4-6H PRN
(Maximum: 60 mg/dose).
Mechanism of Action
Opioid analgesic
Forms Supplied
tablet: 15 mg, 30 mg
oral liquid: 5 mg/mL
acetaminophen with codeine elixir: acetaminophen 32 mg/mL and codeine 1.6 mg/mL
oral liquid: 5 mg/mL
acetaminophen with codeine elixir: acetaminophen 32 mg/mL and codeine 1.6 mg/mL
Comments
Analgesic effect depends upon rate of metabolism of codeine to morphine
and codeine-6-glucuronide, which varies widely in the general
population. Poor metabolizers are at risk of therapeutic failure.
Ultrarapid metabolizers are at risk of opioid overdose.
and codeine-6-glucuronide, which varies widely in the general
population. Poor metabolizers are at risk of therapeutic failure.
Ultrarapid metabolizers are at risk of opioid overdose.
Health Canada
recommends against the use of codeine in children less than 12 years of
age and in children of any age in the postoperative period after
tonsillectomy and/or adeonoidectomy. Consider oral morphine as an
alternative.
recommends against the use of codeine in children less than 12 years of
age and in children of any age in the postoperative period after
tonsillectomy and/or adeonoidectomy. Consider oral morphine as an
alternative.
Do not use as an antitussive.
If maximum doses are used, risk of toxicity, particularly constipation, is increased.
References
44, 132, 394, , 396, 397, 579
Last Edited
2022-06-16 17:29:24