COLISTIMETHATE
(Coly-mycin, Colistin)Standard Prescription
colistimethate__mg by nebulizor __ (frequency) (post chest physio)
colistimethate__mg IV Q__H (__mg/kg/dose)
colistimethate__mg IV Q__H (__mg/kg/dose)
Dosages
Via Inhalation:
(for Pseudomonas Infections in Cystic Fibrosis Patients)
< 6 years: 100 mg nebulized BID post physio
>= 6 years: 150 mg nebulized BID post physio
Doses are halved for the eFlow Altera Nebulizer System due to the efficiency of this nebulizer (not a hospital-supplied device; patients may use their own device)
IV:
1 - 1.5 mg/kg/dose IV Q8H. Maximum 100 mg/dose.
(for Pseudomonas Infections in Cystic Fibrosis Patients)
< 6 years: 100 mg nebulized BID post physio
>= 6 years: 150 mg nebulized BID post physio
Doses are halved for the eFlow Altera Nebulizer System due to the efficiency of this nebulizer (not a hospital-supplied device; patients may use their own device)
IV:
1 - 1.5 mg/kg/dose IV Q8H. Maximum 100 mg/dose.
Mechanism of Action
bacteriocidal antibiotic; destabilizes cytoplasmic membrane of gram negative bacteria (Pseudomonas, E coli, Klebsiella)
Forms Supplied
injection: 150 mg/vial
Comments
Nephrotoxic and neurotoxic when given systemically.
Spectrum of activity is similar to polymyxin.
Injectable form is used for inhalation: prepare by reconstituting vial with 3 mL of normal saline (= 50 mg/mL). Further dilute dose with normal saline for nebulization. Stable for 24 hours, refrigerated.
Spectrum of activity is similar to polymyxin.
Injectable form is used for inhalation: prepare by reconstituting vial with 3 mL of normal saline (= 50 mg/mL). Further dilute dose with normal saline for nebulization. Stable for 24 hours, refrigerated.
For IV dosing in CF: higher doses 5 - 8 mg/kg/24 hours may be required for resistant organisms, however, higher doses are associated with more severe toxicity.
References
32, 44, 306
Last Edited
2022-06-17 04:50:53