DRUG	SUPPLIED	DOSE	COMMENTS
ONDANSETRON (Paeds) (Zofran, Zofran ODT) Mechanism of action: Antiemetic; Selective 5-HT3 receptor antagonist Ref: 521, 522 Last update: 2022-04-08	tablet: 4 mg, 8 mg quick dissolve tablets:  4 mg, 8 mg (ODT tablets) oral solution: 0.8 mg/mL injection: 2 mg/mL	Chemotherapy induced nausea and vomiting:   IV: 0.15 mg/kg/dose (max. 8 mg/dose)  IV Q8H Alternate dosing: 0.45 mg/kg/24 hr (max 24 mg/24 hr) by continuous IV infusion PO:  0.2 mg/kg/dose PO (max. 8 mg/dose) Q8-12H Post-Op Nausea and Vomiting: 0.1 mg/kg/dose IV Q8-12H PRN (usual max. 4 mg/dose) 0.15 mg/kg/dose IV Q8-12H PRN may be used for some neurosurgical procedures (max. 8 mg/dose) Gastroenteritis: IV: 0.15 mg/kg IV once (max. 8 mg/dose) PO: 0.2 mg/kg/dose PO once (max. 8 mg/dose) Alternate PO dosing: 8-15 kg: 2 mg/dose PO once >15-30 kg: 4 mg/dose PO once >30 kg: 8 mg/dose PO once	Limited data for infants less than 6 months for the treatment of gastroenteritis. Quick dissolve tablets disintegrate in mouth in 10-15 seconds. Absorption does not occur via the oral mucosa. Give oral doses 30-60 min. prior to start of chemotherapy. Standard Prescription: ondansetron__mg PO Q__H (PRN) (__mg/kg/dose) ondansetron__mg IV Q__H (PRN) (__mg/kg/dose) ondansetron__mg/kg/hr continuous IV infusion