FUROSEMIDE
(Lasix)Standard Prescription
furosemide __mg IV{PO} Q_H ( mg/kg/dose)
furosemide __mg/kg/hr continuous IV infusion
furosemide __mg/kg/hr continuous IV infusion
Dosages
Infants and children:
Oral Dose:
Initial: 0.5-2 mg/kg/dose PO Q6H - Q24H
Maximum PO dose 4 mg/kg/dose
20-80 mg/dose PO Q6-24H. Maximum 600 mg/24 hr
Parenteral:
10-40 mg/dose IV Q6-12H.
Usual maximum: 80 mg/dose IV
Oral Dose:
Initial: 0.5-2 mg/kg/dose PO Q6H - Q24H
Maximum PO dose 4 mg/kg/dose
Parenteral:
0.5-2 mg/kg/dose /IV Q6-24H PRN.
Usual: 1 mg/kg/dose IV Q6-24H
Maximum single dose is 2 mg/kg/dose IV.
Cont. IV infusion in Critical Care areas 0.1-0.5 mg/kg/hr
Note: older children and adolescents often respond to smaller doses (10-20 mg/dose)
Adults:
Oral dose:20-80 mg/dose PO Q6-24H. Maximum 600 mg/24 hr
Parenteral:
10-40 mg/dose IV Q6-12H.
Usual maximum: 80 mg/dose IV
Mechanism of Action
Loop Diuretic
Forms Supplied
injection: 10 mg/mL (2 mL, 4 mL, 25 mL amps)
tablet: 20 mg, 40 mg, 500 mg
liquid: 10 mg/mL
tablet: 20 mg, 40 mg, 500 mg
liquid: 10 mg/mL
Comments
May cause hypokalemia, alkalosis, dehydration, hyperuricemia, increased calcium and magnesium excretion, nephrocalcinosis.
Ototoxicity may be associated with large IV doses and rapid injection especially in patients with pre-existing renal impairment or taking other ototoxic drugs.
Parenteral doses should be infused slowly over 12 min. or given at a rate not to exceed 0.5 mg/kg/min.
Higher doses may be required in patients with renal failure; to initiate a response. *
Oral Biovailability is poor, 45-65%.
Ototoxicity may be associated with large IV doses and rapid injection especially in patients with pre-existing renal impairment or taking other ototoxic drugs.
Parenteral doses should be infused slowly over 12 min. or given at a rate not to exceed 0.5 mg/kg/min.
Higher doses may be required in patients with renal failure; to initiate a response. *
Oral Biovailability is poor, 45-65%.
References
44, 141, 192
Last Edited
2023-10-23 04:29:07
Standard Prescription:
furosemide __mg IV{PO} Q_H ( mg/kg/dose)
furosemide __mg/kg/hr continuous IV infusion