CYCLOSPORINE

 (Neoral, Sandimmune)

Standard Prescription

cyclosporine__mg IV{PO} Q__H (__mg/kg/24hr)

Dosages

Bone Marrow Transplant:
1.5-3 mg/kg/dose IV Q12H.
5-10 mg/kg/dose PO Q12H.

Solid Organ Transplant:
2-6 mg/kg/dose PO  Q12H

Focal Segmental Glomerulosclerosis (FSGS):
Initial: 1.5 mg/kg/dose PO  Q12H

Rheumatoid Arthritis:
Initial: 1.25 mg/kg/dose PO Q12H
Increment: increase by 0.5-0.75 mg/kg/24 hr if insufficient response after 8 weeks of treatment.
Maximum: 4 mg/kg/24 hr PO

Autoimmune disease:
0.5-1.5 mg/kg/dose PO Q12H

Switching from IV to PO:
1 mg IV = 3 mg PO; recheck serum level in 4-8 days.

Mechanism of Action

Immune suppressant; calcineurin inhibitor

Forms Supplied

Capsules: 10 mg, 25 mg, 50 mg, 100 mg
Injection: 50 mg/mL (1 mL ampule)
Oral solution: 100 mg/mL (50 mL bottle)

Comments

These doses are guidelines only.

Due to the erratic absorption of cyclosporine, and the increased clearance rate of cyclosporine in infants and young children, cyclosporine levels should be monitored regularly to ensure that a therapeutic range is maintained.

See References and Supplementary Materials for Therapeutic Drug Monitoring Table. (see page 378 in hard copies)

Many potential drug interactions; check CPS or consult a pharmacist

See References and Supplementary Materials for Cyclosporine Guidelines (see page 385 in hard copies).

Oral solution is supplied with just ONE oral syringe for measuring dose; please do not discard this syringe.  Any syringe can be used for measuring doses: use same syringe every day; don't wash it - wipe off after use; discard the very first dose drawn up with the syringe (to allow binding to become "saturated").

See the CPS for details on administering the oral liquid.

G-tube:  instill through extension in g-tube button; flush well with 10 mL water, apple or orange juice.

References

32, 44

Last Edited

2021-03-09 05:58:24