ERYTHROMYCIN
Standard Prescription
erythromycin__mg IV{PO} Q__H (__mg/kg/24hr)
erythromycin eye ointment: __cm to__eye(s) Q__H
erythromycin eye ointment: __cm to__eye(s) Q__H
Dosages
PO:
Children: 10-12.5 mg/kg/dose PO TID-QID
Adults: 250-500 mg PO BID-QID
Maximum 1000 mg/dose
Adults: 500-1000 mg IV Q6H
Prokinetic agent (infants & children):
3mg/kg/dose PO QID
Maximum 250 mg/dose
Topical:
Eye Infections: 0.5-1 cm ribbon to affected eye(s) BID-QID.
Prophylaxis of Neonatal Gonococcal or Chlamydial Infections: 1 cm ribbon to each eye x 1
Children: 10-12.5 mg/kg/dose PO TID-QID
Adults: 250-500 mg PO BID-QID
IV:
Children: 5 mg/kg/dose IV Q6H Maximum 1000 mg/dose
Adults: 500-1000 mg IV Q6H
Prokinetic agent (infants & children):
3mg/kg/dose PO QID
Maximum 250 mg/dose
Topical:
Eye Infections: 0.5-1 cm ribbon to affected eye(s) BID-QID.
Prophylaxis of Neonatal Gonococcal or Chlamydial Infections: 1 cm ribbon to each eye x 1
Mechanism of Action
Macrolide antibiotic
Forms Supplied
tablet: 250 mg
injection: 500 mg/vial, 1 g/vial
eye ointment: 0.5%
Erythromycin suspension is no longer manufactured
injection: 500 mg/vial, 1 g/vial
eye ointment: 0.5%
Erythromycin suspension is no longer manufactured
Comments
Bioavailability 18-45%
CYP P450 inhibitor; may increase digoxin, cisapride, carbamazepine and other medication levels if given concurrently. Check for drug interactions.
Rapid IV administration causes severe vein irritation and cardiac arrhythmias (infuse over 60 min. or longer).
Avoid IM route or extravasation.
Perform liver function tests with prolonged, high doses.
CYP P450 inhibitor; may increase digoxin, cisapride, carbamazepine and other medication levels if given concurrently. Check for drug interactions.
Rapid IV administration causes severe vein irritation and cardiac arrhythmias (infuse over 60 min. or longer).
Avoid IM route or extravasation.
Perform liver function tests with prolonged, high doses.
References
6, 44, 165, 620
Last Edited
2022-06-24 04:06:44