FLUCONAZOLE
(Diflucan)Standard Prescription
fluconazole__mg IV{PO} Q__H (__mg/kg/24hr)
Dosages
Children:
3-12 mg/kg/dose PO/IV once daily. Maximum 800 mg daily.
Oropharyngeal or esophageal candidiasis:
6 mg/kg/dose PO once daily x 1. Max 200 mg), then 3 mg/kg/dose PO once daily. Maximum 100 mg/dose
UTI:
3-6 mg/kg/dose PO/IV once daily Maximum 400 mg/dose
Invasive fungal infections:
12 mg/kg/dose PO/IV once daily Maximum 800 mg/dose
Fungal Prophylaxis:
6 mg/kg/dose PO/IV once daily
Maximum 400 mg/dose
Adults:
100-400 mg PO/IV once daily
Maximum 800 mg/dose for invasive systemic fungal infections).
Uncomplicated vulvovaginal candidiasis: 150 mg PO single dose
3-12 mg/kg/dose PO/IV once daily. Maximum 800 mg daily.
Oropharyngeal or esophageal candidiasis:
6 mg/kg/dose PO once daily x 1. Max 200 mg), then 3 mg/kg/dose PO once daily. Maximum 100 mg/dose
UTI:
3-6 mg/kg/dose PO/IV once daily Maximum 400 mg/dose
Invasive fungal infections:
12 mg/kg/dose PO/IV once daily Maximum 800 mg/dose
Fungal Prophylaxis:
6 mg/kg/dose PO/IV once daily
Maximum 400 mg/dose
Adults:
100-400 mg PO/IV once daily
Maximum 800 mg/dose for invasive systemic fungal infections).
Uncomplicated vulvovaginal candidiasis: 150 mg PO single dose
Mechanism of Action
Azole antifungal
Forms Supplied
tablet: 100 mg
injection: 2 mg/mL
suspension: 10 mg/mL
injection: 2 mg/mL
suspension: 10 mg/mL
Comments
Bioavailability >90%.
May cause QT prolongation. Caution in patients with proarrythmic condition or renal and hepatic dysfunction. Use with caution if on other QT prolonging medications.
Dosage adjustment required in renal impairment.
Good CSF and vitreous penetration; achieving concentrations of > 50% of those in serum.
Affects CYP450 resulting in multiple drug interactions. May increase effects/levels of cyclosporine, phenytoin, vincristine, warfarin and zidovudine. Consult pharmacy prior to starting any drug therapy.
For serious invasive fungal disease, consider a loading dose of 12 mg/kg/dose PO/IV x 1 for pediatric patients, or 800 mg PO/IV x 1 for adults.
Requires "Special Authority" from Pharmacare when prescribed for out-patients
May cause QT prolongation. Caution in patients with proarrythmic condition or renal and hepatic dysfunction. Use with caution if on other QT prolonging medications.
Dosage adjustment required in renal impairment.
Good CSF and vitreous penetration; achieving concentrations of > 50% of those in serum.
Affects CYP450 resulting in multiple drug interactions. May increase effects/levels of cyclosporine, phenytoin, vincristine, warfarin and zidovudine. Consult pharmacy prior to starting any drug therapy.
For serious invasive fungal disease, consider a loading dose of 12 mg/kg/dose PO/IV x 1 for pediatric patients, or 800 mg PO/IV x 1 for adults.
Requires "Special Authority" from Pharmacare when prescribed for out-patients
References
6, 44, 93
Last Edited
2022-06-26 06:17:40