FOMEPIZOLE
(Antizol)Standard Prescription
fomepizole__mg IV x 1 dose (__mg/kg/dose) then
fomepizole__mg IV Q H (__mg/kg/dose) x _ doses then
fomepizole__mg IV Q H (__mg/kg/dose)
fomepizole__mg IV Q H (__mg/kg/dose) x _ doses then
fomepizole__mg IV Q H (__mg/kg/dose)
Dosages
Children: (no specific pediatric guidelines)
Initial: 15 mg/kg/dose IV over 30 min
Subsequent doses: 10 mg/kg/dose IV Q12H until methanol level is below 6 mmol/L or ethylene glycol level is below 3 mmol/L or osmole gap is less than 10
If hemodialysis is required, give 10 mg/kg IV 4 hours after start of hemodialysis and 10 mg/kg IV immediately following completion of hemodialysis
Maximum: 1500 mg/dose
Contact BC Drug and Poison Center
Subsequent doses: 10 mg/kg/dose IV Q12H until methanol level is below 6 mmol/L or ethylene glycol level is below 3 mmol/L or osmole gap is less than 10
If hemodialysis is required, give 10 mg/kg IV 4 hours after start of hemodialysis and 10 mg/kg IV immediately following completion of hemodialysis
Maximum: 1500 mg/dose
Mechanism of Action
Potent alcohol dehydrogenase inhibitor to treat methanol and ethylene glycol toxic ingestions and will impair the elimination of ethanol if co-ingested.
Forms Supplied
Injection: 1.5 g/1.5 mL vial
(1000 mg/mL)
(1000 mg/mL)
Comments
Used to treat methanol and ethylene glycol toxic ingestions.
Fomepizole is a potent alcohol dehydrogenase inhibitor and will impair the elimination of ethanol if co-ingested.
May cause bradycardia, tachycardia, hypotension, headache, dizziness, nausea, bad taste/smell. Seizures and fever have been reported.
Renal elimination; increased toxicity in renal failure; no dosage recommendations available for renal impairment.
Fomepizole is a potent alcohol dehydrogenase inhibitor and will impair the elimination of ethanol if co-ingested.
May cause bradycardia, tachycardia, hypotension, headache, dizziness, nausea, bad taste/smell. Seizures and fever have been reported.
Renal elimination; increased toxicity in renal failure; no dosage recommendations available for renal impairment.
References
1, 4, 19, 44
Last Edited
2021-12-07 20:56:50