GANCICLOVIR
(Cytovene)Standard Prescription
ganciclovir__mg IV q__h (__mg/kg/24hr)
Dosages
Treatment of CMV disease:
5 mg/kg/dose IV Q12H for a minimum 14-21 days and until plasma CMV PCR negative
CMV preemptive therapy/treatment of asymptomatic viremia:
5 mg/kg/dose IV Q12H
CMV prophylaxis for post-solid organ transplant:
5 mg/kg/dose IV once daily x 7 days/week or 6 mg/kg/dose IV once daily x 5 days/week
5 mg/kg/dose IV Q12H for a minimum 14-21 days and until plasma CMV PCR negative
CMV preemptive therapy/treatment of asymptomatic viremia:
5 mg/kg/dose IV Q12H
CMV prophylaxis for post-solid organ transplant:
5 mg/kg/dose IV once daily x 7 days/week or 6 mg/kg/dose IV once daily x 5 days/week
Mechanism of Action
Antiviral; acyclic analog of guanosine
Forms Supplied
injection: 500 mg/vial
Comments
First line for CMV infection.
Dose reduction required in renal impairment and hemodialysis patients (see Parenteral Manual online).
5 day per week dosing schedule allows patients to receive IV therapy as out-patients
Use valganciclovir orally as there is no oral formulation of ganciclovir. Note: valganciclovir can NOT be substituted for ganciclovir on a one-to-one basis.
References
6, 44
Last Edited
2022-07-02 22:49:05