FILGRASTIM
(G-CSF, granulocyte colony stimulating factor, Neupogen, Nivestym)Standard Prescription
G-CSF mcg IV/SC Q__H ( mcg/kg/dose)
Dosages
Febrile Neutropenia Prophylaxis:
Adults and Children:
5 mcg/kg/dose SC once daily; continue until ANC is adequate as per protocol
Adults and Children:
5 mcg/kg/dose SC once daily; continue until ANC is adequate as per protocol
Peripheral stem cell mobilization:
10 mcg/kg/dose SC 4 hrs prior to apheresisMechanism of Action
Recombinant human granulocyte colony-stimulating factor
Forms Supplied
Injection: 300 mcg/mL, 1 mL vials
Comments
Endpoints of filgrastim therapy vary between different chemotherapy protocols.
Adverse effects may include bone pain, fever, and rash.
SC route preferred because of prolonged serum level compared with IV route.
Adverse effects may include bone pain, fever, and rash.
SC route preferred because of prolonged serum level compared with IV route.
References
43, 44, 518
Last Edited
2022-06-25 22:18:58