ISONIAZID
(INH)Standard Prescription
isoniazid mg PO__(frequency) ( mg/kg/24 hr)
Dosages
Active Tuberculosis:*
Children: 10-15 mg/kg/dose PO daily.** or 20-30 mg/kg/dose three times weekly
Maximum: 300 mg/dose on daily regimen or 900 mg/dose on three times weekly regimen.
Latent Tuberculosis:
10-15mg/kg/dose PO daily or
20-30mg/kg/dose twice weekly
Maximum: 300mg/dose on daily regimen, 900mg/dose on twice weekly regimen
Children: 10-15 mg/kg/dose PO daily.** or 20-30 mg/kg/dose three times weekly
Maximum: 300 mg/dose on daily regimen or 900 mg/dose on three times weekly regimen.
Latent Tuberculosis:
10-15mg/kg/dose PO daily or
20-30mg/kg/dose twice weekly
Maximum: 300mg/dose on daily regimen, 900mg/dose on twice weekly regimen
Mechanism of Action
Antitubercular agent
Forms Supplied
tablet: 300 mg
liquid: 10 mg/mL
liquid: 10 mg/mL
Comments
*Should not be used alone for treatment; combine with other antitubercular agents.
Adverse Drug Reactions: mild hepatic enzyme elevation, hepatitis, peripheral neuritis, hypersensitivity. Hepatotoxic effects more common with higher dose or in combination with rifampin.
**In patients with low level isoniazid resistance, 15-20 mg/kg/dose PO daily may be used.
References
6, 44, 134, 167, 203
Last Edited
2022-07-03 03:47:21