AMIODARONE
(Cordarone)Standard Prescription
IV Loading Dose: _ mg IV over _ min (_mg/m2/dose)
Dosages
Loading Dose:
Children PO:
<1 yr: 600-800 mg/1.73 m2/24 hr PO div Q12-24H X 4-14 days (until adequate control achieved then reduce to maintenance).
>= 1 yr: 10-15 mg/kg PO div. Q12-24H X 4-14 days (until adequate control achieved then reduce to maintenance).
Children IV:
Post-op cardiac surgery patients:
2-5 mg/kg/dose IV over 20-30 min
Inadequate response: 1 mg/kg/dose IV over 10 min
Adequate response: begin maintenance infusion
PALS/ACLS:
<1 yr: 200-400 mg/1.73 m2/24 hr PO div. Q12-24H.
>= 1 yr: 5 mg/kg/24 hr PO div. Q12-24H
Children IV:
5-15 mcg/kg/min. IV continuous infusion to maximum of 15 mcg/kg/min or 20 mg/kg/24hr.
Children PO:
<1 yr: 600-800 mg/1.73 m2/24 hr PO div Q12-24H X 4-14 days (until adequate control achieved then reduce to maintenance).
>= 1 yr: 10-15 mg/kg PO div. Q12-24H X 4-14 days (until adequate control achieved then reduce to maintenance).
Children IV:
Post-op cardiac surgery patients:
2-5 mg/kg/dose IV over 20-30 min
Inadequate response: 1 mg/kg/dose IV over 10 min
Adequate response: begin maintenance infusion
PALS/ACLS:
5 mg/kg/dose IV/IO rapid bolus for pulseless VT or VF; infuse over 20-30 min for perfusing tachycardias (max 300 mg/dose); may repeat X 2 doses
Maintenance:
Children PO:<1 yr: 200-400 mg/1.73 m2/24 hr PO div. Q12-24H.
>= 1 yr: 5 mg/kg/24 hr PO div. Q12-24H
Children IV:
5-15 mcg/kg/min. IV continuous infusion to maximum of 15 mcg/kg/min or 20 mg/kg/24hr.
Mechanism of Action
Class III antiarrhythmic, alpha and beta blocker.
Forms Supplied
tablet: 200 mg
oral liquid (BCCH): 5 mg/mL
injection: 50 mg/mL (3 mL amp.)
Comments
Long t½, extensive distribution.
IV loading dose can cause bradycardia, hypotension, nausea and vomiting.
IV loading doses < 2 mg/kg have less incidence of adverse hemodynamic consequences.
Continuous ECG monitoring is recommended while receiving IV amiodarone
Onset of action: 3 days to 3 weeks.
Use with caution in patients with hepatic dysfunction.
NOTE: In some clinical situations, maximum dosages may need to be exceeded. This should only be done in consultation with Cardiology.
IV loading dose can cause bradycardia, hypotension, nausea and vomiting.
IV loading doses < 2 mg/kg have less incidence of adverse hemodynamic consequences.
Continuous ECG monitoring is recommended while receiving IV amiodarone
Significant drug interactions exist, especially with drug metabolized by CYP450 (e.g. warfarin and digoxin); consult Micromedex for a complete list.
Use with caution in patients with hepatic dysfunction.
NOTE: In some clinical situations, maximum dosages may need to be exceeded. This should only be done in consultation with Cardiology.
References
1, 15, 37, 55, 141, 588
Last Edited
2022-06-09 04:38:36