MALARONE
(ATOVAQUONE / PROGUANIL HCl)Standard Prescription
Malarone __ tablet(s) PO daily to be started 1 day before entering endemic area, continue daily throughout stay, and for 7 days after departure.
Dosages
**doses are for adult tablets**
Chemoprophylaxis of (chloroquine-resistant) Plasmodium falciparum malaria:
31-40 kg: 0.75 tablet/dose PO daily
> 40 kg and adults: 1 tablet/dose PO daily
Treatment of uncomplicated (chloroquine-resistant) Plasmodium falciparum malaria:
5-8 kg: 0.5 tablet/dose PO daily x 3 days
> 8-10 kg: 0.75 tablet/dose PO daily x 3 days
> 10-20 kg: 1 tablet/dose PO daily x 3 days
> 20-30 kg: 2 tablets/dose PO daily x 3 days
> 30-40 kg: 3 tablets/dose PO daily x 3 days
> 40 kg and adults: 4 tablets/dose PO daily x 3 days
Chemoprophylaxis of (chloroquine-resistant) Plasmodium falciparum malaria:
<10kg - see Comments*
11-20 kg: 0.25 tablet/dose PO daily
21-30 kg: 0.5 tablet/dose PO daily 31-40 kg: 0.75 tablet/dose PO daily
> 40 kg and adults: 1 tablet/dose PO daily
Treatment of uncomplicated (chloroquine-resistant) Plasmodium falciparum malaria:
5-8 kg: 0.5 tablet/dose PO daily x 3 days
> 8-10 kg: 0.75 tablet/dose PO daily x 3 days
> 10-20 kg: 1 tablet/dose PO daily x 3 days
> 20-30 kg: 2 tablets/dose PO daily x 3 days
> 30-40 kg: 3 tablets/dose PO daily x 3 days
> 40 kg and adults: 4 tablets/dose PO daily x 3 days
Mechanism of Action
Antimalarial
Forms Supplied
Tablet (adult): atovaquone 250 mg / proguanil HCl 100 mg (equivalent to proguanil base 87.4 mg)
Tablet (pediatric): atovaquone 62.5 mg / proguanil HCl 25 mg (equivalent to proguanil base 21.86 mg)
Available but not stocked at BCCH:
Comments
Contraindicated in patients with severe renal impairment (CrCl < 30).
Should be taken at the same time everyday with food/milky drink to increase absorption.
Repeat dose if emesis occurs within 1 hour after administration.
Tablets should preferably be swallowed whole, but may be crushed and mixed with condensed milk just prior to administration to mask bitter taste.
Common side effects: abdominal pain, nausea, vomiting, diarrhea.
May cause mild transient elevation of liver aminotransferase levels.
Prophylactic dose should begin 1 day before exposure and continue for 7 days after leaving endemic area.
Should be taken at the same time everyday with food/milky drink to increase absorption.
Repeat dose if emesis occurs within 1 hour after administration.
Tablets should preferably be swallowed whole, but may be crushed and mixed with condensed milk just prior to administration to mask bitter taste.
Common side effects: abdominal pain, nausea, vomiting, diarrhea.
May cause mild transient elevation of liver aminotransferase levels.
Prophylactic dose should begin 1 day before exposure and continue for 7 days after leaving endemic area.
*For chemoprophylaxis in children ≤10 kg, use pediatric tablet:
5-8 kg: 0.5 pediatric tablet/dose PO daily;
9-10 kg: 0.75 pediatric tablet/dose PO daily
References
6, 22, 44
Last Edited
2022-07-06 18:22:03