METRONIDAZOLE
(Flagyl)Standard Prescription
metronidazole__mg IV{PO} Q__H (__mg/kg/24hr)
metronidazole vaginal cream: one applicatorful PV__(frequency) x__days
metronidazole vaginal cream: one applicatorful PV__(frequency) x__days
Dosages
Children:
5-15 mg/kg/dose PO/IV Q8H
Max. 500 mg/dose
Crohn's Disease
10 mg/kg/dose PO BID to TID. Max. 500 mg/dose
Clostridium difficile:
Children: Mild to moderate infection, first or second episode: 7.5 mg/kg/dose PO QID x 10 days
Severe complicated infection, with vancomycin: 10 mg/kg/dose IV Q8H x 10 days
Max. 500 mg/dose
Gastrointestinal tract decontamination in intestinal failure:
10 mg/kg/dose PO BID x 1-2 weeks
Adults:
500 mg PO/IV BID to TID
5-15 mg/kg/dose PO/IV Q8H
Max. 500 mg/dose
Perforated Appendicitis:
IV: 30 mg/kg/dose IV Q24H
Max. 1000 mg/dose
PO: 10 mg/kg/dose PO Q8H
Max: 500 mg/dose
IV: 30 mg/kg/dose IV Q24H
Max. 1000 mg/dose
PO: 10 mg/kg/dose PO Q8H
Max: 500 mg/dose
10 mg/kg/dose PO BID to TID. Max. 500 mg/dose
Clostridium difficile:
Children: Mild to moderate infection, first or second episode: 7.5 mg/kg/dose PO QID x 10 days
Severe complicated infection, with vancomycin: 10 mg/kg/dose IV Q8H x 10 days
Max. 500 mg/dose
Vaginal Therapy:
One applicatorfull PV nightly x 10 daysGastrointestinal tract decontamination in intestinal failure:
10 mg/kg/dose PO BID x 1-2 weeks
Adults:
500 mg PO/IV BID to TID
Mechanism of Action
Antibiotic; amebicide; antiprotozoal
Forms Supplied
tablet: 250 mg, 500 mg
suspension (BCCH): 50 mg/mL
injection: 5 mg/mL (100 mL)
vaginal cream: 10%
suspension (BCCH): 50 mg/mL
injection: 5 mg/mL (100 mL)
vaginal cream: 10%
Comments
Excellent oral bioavailability of 100%.
Avoid alcohol containing preparations for 24 hr after dose to prevent disulfiram-like reactions.
Avoid alcohol containing preparations for 24 hr after dose to prevent disulfiram-like reactions.
Refer to BCCH Pediatric C. difficile guidelines and Adult C. difficile guidelines.
Once daily IV dosing used only for perioperative period until able to tolerate oral regimen
References
6, 44, 188, 371, 686, 687
Last Edited
2023-04-04 01:59:45