MYCOPHENOLATE

 (MMF, Apo, Sandoz Cellcept, Mycophenolate Sodium, Myfortic)

Standard Prescription

mycophenolate mofetil__mg PO/IV Q__H (__mg/m2/dose)
mycophenolate sodium__mg PO Q__H (__mg/m2/dose)

Dosages

Kidney Transplant:
Mycophenolate mofetil:
600 mg/m2/dose PO/IV BID
Maximum: 1000 mg/dose

Mycophenolate sodium (Myfortic®):
432 mg/m2/dose PO BID (max: 720 mg BID)
BSA 1.19-1.58 m2: 540 mg PO BID
BSA > 1.58 m2: 720 mg PO BID

Nephrotic Syndrome:
600 mg/m2/dose BID
Maximum: 1000 mg/dose

GVHD Prophylaxis for HSCT
15 mg/kg/dose IV Q8H. Maximum 1000 mg/dose
Once able to tolerate oral, switch to 15 mg/kg/dose PO BID-TID. Maximum 1000 mg/dose

Mechanism of Action

Immune suppressant

Forms Supplied

Apo, Sandoz brands (mycophenolate mofetil): 250 mg capsule, 500 mg tablet

Cellcept suspension (mycophenolate mofetil): 200 mg/mL

Myfortic (mycophenolate sodium) EC tablet: 180 mg, 360 mg

injection (mycophenolate mofetil): 500 mg/vial

Comments

Mycophenolate mofetil 1000 mg = mycophenolate sodium (Myfortic) 720 mg.

Myfortic
 tablets are enteric coated; do not crush, chew or split the tablets.

Teratogenic: women of reproductive potential must be counselled on pregnancy planning and prevention.

Other organ transplants (heart, liver, lung, bowel, etc,) follow specific protocols.

References

32, 44, 72, 75, 560

Last Edited

2022-07-27 20:31:22