ACETAZOLAMIDE
(Diamox)Standard Prescription
acetazolamide __mg PO/IV Q__H (__mg/kg/dose)
Dosages
Diuretic:
5 mg/kg/dose PO/IV daily or every other day
Urine Alkalinization:
5 mg/kg/dose IV/PO repeated 2-3 times over 24 hr
5 mg/kg/dose PO/IV daily or every other day
Glaucoma:
2.5-7.5 mg/kg/dose PO/IV Q6-8H
Maximum: 1000 mg/24 hr
2.5-7.5 mg/kg/dose PO/IV Q6-8H
Maximum: 1000 mg/24 hr
Increased Intracranial Pressure:
Initial: 6.7 mg/kg/dose PO/IV TID
Maximum: 100 mg/kg/24 hr or 2000 mg/24 hr (whichever is lower)
Initial: 6.7 mg/kg/dose PO/IV TID
Maximum: 100 mg/kg/24 hr or 2000 mg/24 hr (whichever is lower)
Seizures:
Initial: 2 mg/kg/dose PO BID
Maintenance: 4-10 mg/kg/dose PO BID to TID (8-30 mg/kg/24 hr)
(Limited additional benefit above 16 mg/kg/24 hr)
Initial: 2 mg/kg/dose PO BID
Maintenance: 4-10 mg/kg/dose PO BID to TID (8-30 mg/kg/24 hr)
(Limited additional benefit above 16 mg/kg/24 hr)
Maximum: 30 mg/kg/24 hr or 1000 mg/24 hr (whichever is lower)
5 mg/kg/dose IV/PO repeated 2-3 times over 24 hr
Mechanism of Action
Diuretic; carbonic anhydrase inhibitor
Forms Supplied
Tablet: 250 mg
Injection: 500 mg/vial
Oral suspension (BCCH): 25 mg/mL
Injection: 500 mg/vial
Oral suspension (BCCH): 25 mg/mL
Comments
Avoid if allergic to sulfonamides.
Diuresis more effective given every other day or 2 out of 3 days only.
250 mg tablets can be quartered. May adjust dose according to tablet increments.
IM injections may be painful and are not recommended.
Take with food to minimize GI irritation, decreased appetite.
Adverse Effects: GI irritation, decreased appetite, metabolic acidosis, electrolyte imbalance, paresthesia, polyuria.
Bicarbonate replacement therapy may be required in long term use.
Diuresis more effective given every other day or 2 out of 3 days only.
250 mg tablets can be quartered. May adjust dose according to tablet increments.
IM injections may be painful and are not recommended.
Take with food to minimize GI irritation, decreased appetite.
Adverse Effects: GI irritation, decreased appetite, metabolic acidosis, electrolyte imbalance, paresthesia, polyuria.
Bicarbonate replacement therapy may be required in long term use.
References
32, 44, 361
Last Edited
2023-01-12 06:13:08