PROCAINAMIDE
Standard Prescription
procainamide __mg IV x 1 dose (__mg/kg/dose)
procainamide __mcg/kg/min IV infusion
procainamide __mcg/kg/min IV infusion
Dosages
Children:
JET:
IV (loading dose):
3-6 mg/kg/dose over 20 mins.
Maximum: 100 mg/dose.
May repeat every 5-10 mins to a maximum of 15 mg/kg.
IV Maintenance: 20-80 mcg/kg/min. by continuous IV infusion. Maximum: 80 mcg/kg/min or 2 g/24 hr or 6 mg/min.
SVT:
10-15 mg/kg//dose IV/IO over 30 min (Maximum 1000 mg/dose)
Challenge for Brugada syndrome:
15 mg/kg/dose up to a maximum of 1000 mg over 20 minutes
JET:
IV (loading dose):
3-6 mg/kg/dose over 20 mins.
Maximum: 100 mg/dose.
May repeat every 5-10 mins to a maximum of 15 mg/kg.
IV Maintenance: 20-80 mcg/kg/min. by continuous IV infusion. Maximum: 80 mcg/kg/min or 2 g/24 hr or 6 mg/min.
SVT:
10-15 mg/kg//dose IV/IO over 30 min (Maximum 1000 mg/dose)
Challenge for Brugada syndrome:
15 mg/kg/dose up to a maximum of 1000 mg over 20 minutes
Mechanism of Action
Class Ia antiarrhythmic agent.
Forms Supplied
Injection: 100 mg/mL - 10 mL
Comments
Class Ia antiarrhythmic with anticholinergic and local anesthetic and negative inotropic effects
May cause lupus-like syndrome.
Given IV may cause hypotension, AV block, widening of QRS.
Widening of QRS > 0.02 sec. suggests toxicity.
Short half life requires frequent dosing.
Adjust dose in renal failure
Do not routinely use with amiodarone
References
37, 141, 242, 281, 591
Last Edited
2022-09-08 05:19:40