URSODIOL
(Urso, ursodeoxycholic acid)Standard Prescription
ursodiol__mg PO__(frequency) (__mg/kg/24hr)
Dosages
TPN-induced cholestasis/biliary atresia:
10 mg/kg/dose PO TID
Cystic Fibrosis:
10-15 mg/kg/dose PO BID
Prophylactic Therapy of Sinusoidal obstructive Syndrome (SOS) in BMT patients:
15 mg/kg/dose PO once daily or 5-10 mg/kg/dose PO BID beginning 2 weeks prior to transplant. Mechanism of Action
Gallstone dissolution agent; anticholelithic
Forms Supplied
tablet: 250 mg
suspension (BCCH): 25 mg/mL
suspension (BCCH): 25 mg/mL
Comments
May cause diarrhea and worsen malabsorption by decreasing bile salt pool.
Aluminum-based antacids (Almagel, Amphogel, Maalox) can bind to ursodiol and decrease its absorption; do not use antacids within 2 hours of ursodiol dose.
Take with food.
In patients with Primary Sclerosing Cholangitis, maximum dose is 20 mg/kg/day.
Monitor liver enzymes and bilirubin while on therapy.
Aluminum-based antacids (Almagel, Amphogel, Maalox) can bind to ursodiol and decrease its absorption; do not use antacids within 2 hours of ursodiol dose.
Take with food.
In patients with Primary Sclerosing Cholangitis, maximum dose is 20 mg/kg/day.
Monitor liver enzymes and bilirubin while on therapy.
References
44, 311, 312, 313, 314
Last Edited
2019-08-30 20:20:06