AZATHIOPRINE
(Imuran)Standard Prescription
azathioprine __mg IV/PO daily (__mg/kg/24hr)
Dosages
Transplantation, solid organ:
Initial: 3-5 mg/kg/24 hr IV or PO daily beginning at the time of transplant.
Maintenance: 1-3 mg/kg/24 hr IV or PO daily.
Inflammatory Bowel Disease:
1-3 mg/kg/day IV/ PO daily.
Maximum daily dose 4 mg/kg/24 hours, or 200 mg per day.
Doses higher than 2 mg/kg should be guided by thiopurine metabolite levels.
Mechanism of Action
Immune suppressant
Forms Supplied
tablet: 50 mg
injection: 100 mg/vial
suspension (BCCH): 10 mg/mL
Comments
Bone marrow suppressive.
Monitor hematological status and liver function
May also cause rash, stomatitis, GI disturbances.
Reduce dose in renal impairment.
allopurinol significantly interacts with azathioprine; reduce dose of azathioprine by 1/3 to 1/4 of usual dose
Refer to Nursing Policies under "cytotoxic drugs" for safe handling, administration, etc.
Monitor hematological status and liver function
May also cause rash, stomatitis, GI disturbances.
Reduce dose in renal impairment.
allopurinol significantly interacts with azathioprine; reduce dose of azathioprine by 1/3 to 1/4 of usual dose
Refer to Nursing Policies under "cytotoxic drugs" for safe handling, administration, etc.
References
1, 44
Last Edited
2018-11-26 06:01:29