CLOBAZAM
(Frisium)Standard Prescription
clobazam__mg PO Q__H (__mg/kg/24hr)
Dosages
Seizures:
Children > 2 years
<=30 kg:
Children > 2 years
<=30 kg:
Initial: 2.5-5 mg/dose PO daily
Increment: 2.5-5 mg/dose PO daily every 5-7 days
Maintenance: 0.5-1 mg/kg/dose PO daily (Divide doses > 20 mg to BID) Maximum: 30 mg/dose PO daily (In rare cases, may use higher maximum based on individual clinical response)
> 30 kg:
Initial: 5-10 mg/dose PO daily
Increment: 5-10 mg/dose PO daily every 5-7 days
Maintenance: 0.5-1 mg/kg/dose PO daily. (Consider dividing doses > 20 mg to BID)
Maximum: 30 mg/dose PO daily (In rare cases, may use higher maximum based on individual clinical response) Mechanism of Action
Benzodiazepine; anticonvulsant, A GABAa receptor agonist and may affect sodium channels and voltage-sensitive calcium channels.
Forms Supplied
tablet: 10 mg
oral liquid (BCCH): 1 mg/mL
oral liquid (BCCH): 1 mg/mL
Comments
Use lowest effective dose
Patients who show no response to 1 mg/kg/24 hr are unlikely to respond to higher doses
If daily dose is divided, the higher portion should be taken at night.
CYP2C19 poor metabolizers may require slower titration
Adverse effects: drooling, sedation, increased appetite, paradoxical reactions, behavioural changes (more likely in patients with ADHD or previous behavioural problem
Patients who show no response to 1 mg/kg/24 hr are unlikely to respond to higher doses
If daily dose is divided, the higher portion should be taken at night.
CYP2C19 poor metabolizers may require slower titration
Adverse effects: drooling, sedation, increased appetite, paradoxical reactions, behavioural changes (more likely in patients with ADHD or previous behavioural problem
References
32, 44 , 362
Last Edited
2022-06-17 04:39:25